Here, we see that Adam and Eve produced another offspring. It has been noted that this was not just the third child they had had, but the important part is that Seth’s line replaced Abel. There could have been many children in between.
She says that God had appointed her another seed. She’d come to realize what James 1:17 says, “Every good gift and every perfect gift is from above, and cometh down from the Father of lights, with whom is no variableness, neither shadow of turning.” Cain had boasted of himself, he felt his son was his own. However, Eve realized that Seth, like Abel, was “from the Lord.”
This shows the difference between the lines of thinking. Sure, they were sinners, too. Sin was already heavy on the world, weighing it down with pain. However, Cain and the others were focused on themselves, and their anger and violence against each other grew greatly. Seth’s line didn’t focus on the Lord with all their hearts. However, this focus on the Lord leads to the next verse, which closes out the chapter.